Abstract: According to the anthrax characteristic of Yangquan 5th coal mine that the15# coal seam is inflammable and Spontaneous Combustion Period of the seam is short，the Spontaneous Combustion character and oxygen uptake process of coal were studied through the heating-programmed oxidation experiment. Inhibitory effect of different kinds of inhibitor on coal seam spontaneous combustion was studied during the experiment for which CO was selected as the index gas and also ICO was selected as the auxiliary index. The concentration ratio for the best inhibitory effect was determined as 30% calcium chloride, 15% magnesium chloride, 30% calcium hydroxide and 20% sodium silicate which could provide experimental basis for Spontaneous Combustion prevention.